| 貨號(hào) | 規(guī)格 | 價(jià)格 | 上海 | 北京 | 武漢 | 南京 | 購買數(shù)量 |
|---|---|---|---|---|---|---|---|
S80208-1mg |
98.1% | ￥240.00 | 10 | - | - | - |
|
S80208-2mg |
98.1% | ￥420.00 | 10 | - | - | - |
|
S80208-5mg |
98.1% | ￥580.00 | 7 | - | - | - |
|
S80208-10mg |
98.1% | ￥1100.00 | 8 | - | - | - |
|
S80208-25mg |
98.1% | ￥2250.00 | 6 | - | - | - |
|
S80208-50mg |
≥98% | ￥3700.00 | 貨期：2-3天 | - | - | - |
|
S80208-100mg |
≥98% | ￥5300.00 | 貨期：2-3天 | - | - | - |
|
XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively
| 產(chǎn)品描述： | XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點(diǎn)： | IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation);Tyrosinase;PPAR | ||||||||||||||||||||
| 體外研究： | XMD8-87 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD8-87 has IC50s of 38 nM and 113 nM for the D163E and R806Q mutations. The effects of XMD8-87 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD8-87 | ||||||||||||||||||||
| 參考文獻(xiàn)： | 1. Maxson JE, et al. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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北京